RC2NB 4.0: Transforming research in MS and Neuroimmunology

December 15, 2023

Basel (Switzerland)


RC2NB 4.0: Transforming research in MS and Neuroimmunology

Hosted by:

Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB)


You are cordially invited to join the "RC2NB 4.0: Transforming research in MS and Neuroimmunology" symposium hosted by the Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB).

This symposium offers an exceptional opportunity for knowledge exchange on hot topics in MS and Neuroimmunology. There is an impressive lineup of speakers and engaging sessions planned, which will stimulate your thinking and provide valuable insights.


09:30 Welcome Coffee

10:00 Welcome by Ludwig Kappos and Cristina Granziera

10:10 – 10:40 Opening lecture: Learning from other areas of medicine

10:10 – 10:40
The patient’s digital twin
Tobias Heimann, Head of Artificial Intelligence Germany, Siemens Healthineers

10:40 – 12:00

Session 1: Neuroimmunological mechanisms in MS
Chairs: Renaud Du Pasquier (Lausanne, CH) and Reinhard Hohlfeld (Munich, DE)

10:40 – 11:00
Innovative concepts in neuroimmunology
Amit Bar-Or, Philadelphia, PA, USA

11:00 – 11:15
The B-cell perspective of MS
Tobias Derfuss, Basel, CH

11:15 – 11:30
A role for IgA-producing cells in MS?
Anne-Katrin Pröbstel, Basel, CH

11:30 – 12:00
The success story of B-cell directed therapy and new therapeutic targets
Stephen Hauser, San Francisco, CA, USA

12:00 – 13:00

Lunch break & poster session

13:00 – 14:30

Session 2: Fluid and imaging biomarkers in MS
Chairs: Tanuja Chitnis (Boston, US) and Frederik Piehl (Stockholm, SE)

13:00 – 13:30
What can be said at all can be clearly quantified, and whereof one cannot quantify thereof one must be silent...
Daniel S. Reich, Bethesda, MD, USA

13:30 – 13:50
Body fluid biomarkers in MS – finally on target?
Jens Kuhle, Basel, CH

13:50 – 14:00
The role of complement in MS
Johanna Oechtering, Basel, CH

14:00 – 14:20
Imaging axonal damage and repair in MS: the INsIDER experience
Cristina Granziera, Basel, CH

14:20 – 14:30
Mechanisms of clinical worsening independent of inflammatory activity in MS: an advanced MRI perspective
Alessandro Cagol, Basel, CH

14:30 – 15:00

Coffee break & poster session

15:00 – 16:30

Session 3: Clinical trials, disease monitoring, cohort studies and pragmatic clinical trials in MS
Chairs: Maria Pia Sormani (Genova, IT) and Urs Fischer (Basel, CH)

15:00 – 15:30
Meta-epidemiology of clinical trials
John P.A. Ioannidis, Stanford, CA, USA

15:30 – 15:40
The Swiss Multiple Sclerosis Cohort: a 10-year investment in quality
Giulio Disanto, Lugano, CH; Jens Kuhle, Basel, CH

15:40 – 15:50
Neurostatus eEDSS
Marcus D’Souza, Basel, CH

15:50 – 16:10
Digital Biomarkers for pwMS - the dreaMS project
Johannes Lorscheider, Tim Woelfle, Basel, CH

16:10 – 16:30
Pragmatic trials in MS: a novel journey
Lars Hemkens, Basel, CH

16:30 – 17:00

Coffee break & poster session

17:00 – 18:00

Session 4: Towards digital twins in neuroimmunology?
Chairs: Torsten Schwede (Basel, CH) and Jan Hillert (Stockholm, SE)

17:00 – 17:15
The Big MS data network
Jan Hillert, Stockholm, SE

17:15 – 17:30
Big (great) data in immunobiology: is more always better?
Manfred Claassen, Tübingen, DE

17:30 – 17:45
Federated Learning as an alternative to data transfer?
Björn Tackenberg, Hoffmann La Roche, Basel, CH

17:45 – 18:00
Big (great) data from clinical trials: what can we learn
Amit Khanna, Novartis, Basel, CH


Closing remarks – RC2NB 4.0: Τα πάντα ρει, μηδέποτε κατά τ‘αυτό μένειν, Ludwig Kappos (Basel, CH)
18:15 Apero Riche


15th of December, 2023



Maurice E. Müller Saal,

Spitalstrasse 41,

4056 Basel