Network. Behaviour. Recovery – Understanding changes in connectivity after stroke

Complex brain functions (i.e., language) rely on the integrity of distributed and bilaterally organized brain networks. Brain network alterations caused by a distinct stroke lesion can be studied through structural or functional connectivity. However, how can structural and functional brain connectivity be determined in stroke patients and be used to predict poststroke deficits and their recovery?

This 2-day international meeting in Freiburg, Germany, will bring together stroke researchers from different institutions and countries to discuss recent methodological advances in structural and functional connectivity to understand the impact of brain connectivity changes on behavioural deficits and their recovery.

Different sessions and plenty room for discussion will give a profound starting point about functional and structural connectivity in stroke patients and present the most recent methodological approaches in structural/functional connectivity, including technical challenges and limitations. Moreover, the meeting intends to present clinical examples of the application of diverse methodological approaches to determine the "most appropriate" one for a specific clinical question. Lastly, it enclose an outlook for the future, including a platform for combining forces in order to build more extensive databases and/or collaboration across centres.

This event will also be broadcasted using Webex.

Friday, February 3^rd, 2023

8:00 : Registration

8:20: Prof. Hein (Dean of the Faculty); Prof. Weiller

Opening remarks

Session 1 Determining structural connectivity in stroke patients

8:35

Maurizio Corbetta (Padua, Italy)

Brain networks and criticality alterations in stroke

9:00

Michel Thiebaut de Schotten (Bordeaux, FR)

Disconnectome mapping - The BCB toolkit 

 9:25

Aaron Boes (Iowa City, USA)

Using lesion location and lesion-associated networks to predict post-stroke deficits – methodological challenges

9:50

Jürgen Henning (Freiburg, Germany)

Discussion

10:20    Coffee break

10:50

Max Wawryziak (Leipzig, GER)

Disconnectome mapping – validating the methodolocial approach

11:00

Orionas-Vasilis Saprikis (Freiburg, GER)

Tract mask-based lesion mapping

 11:10

Marco Reisert (Freiburg, GER)

Streamline-based lesion-symptom mapping – a global tractography approach (NORA toolbox)

 11:20

Chris Rorden (Columbia, USA)

Measuring structural and functional connectivity longitudinally

 11:50

Hans-Otto Karnath (Tübingen, GER)

Discussion

 12:20

Lunch

Session 2 Determining functional connectivity in stroke patients

13:20

Michael Fox (Boston, USA)

Lesion network mapping

13:45

Pierre LeVan (Calgary, CA)

How to quantify functional connectivity when it fluctuates so much?

14:10

Susan Duncan (Louisane, USA)

Interindividual changes in functional connectivity

14:35

Claus Hilgetag  (Hamburg, Germany)

Inferring causal functional contributions and interactions from stroke lesions

15:00

Lorenzo Pini (Padua, Italy)

A principal component functional dysconnectivity approach in stroke

 15:20

Steven Small (Dallas, UK) & Ana Solodkin (Dallas, UK)

Discussion

 15:50    Coffee break

 Session 3 Methods and Perspective

16:20

Andreas Horn (Boston, USA)

Using causal sources of information to map the human connectome

16:35

Michael Tangermann (Nijmegen, NDL)

Brain computer interfaces: a novel closed-loop possible approach for stroke recovery

16:50

Stephanie J Forkel (Nijmegen, NLD)

Language Functions and the connected brain

17:05

Cornelius Weiller (Freiburg, GER)

Anatomically defined interaction hubs in the brain

17:20

Matt Lambon Ralph (Cambridge, UK)

Some other key ingredients for future research: cognition, computational models and copious data

17:50

Ferdinand Binkofski (Aachen, GER) & Christian Grefkes (Frankfurt, GER)

Discussion

 Saturday, February 4^rd, 2023

 Session 4 Structural and functional connectivity as a measure of post stroke deficits

9:00

Argye Hillis (Baltimore, USA)

Disruptions of the human connectome resulting in hemispatial neglect after right hemisphere stroke

9:20

Janina Wilmskoetter (Charleston, USA)

Measures of structural brain connectivity in post-stroke aphasia und dysphagia

 9:40

Friedhelm Hummel (Geneve, CHE)

Structural connectomes in post-stroke motor deficits

 10:00

Bastian Cheng (Hamburg, GER)

Connectomics in cerebral small vessel disease - results from the Hamburg City Health Study

 10:10

Anika Stockert (Leipzig, GER)

Lesion network mapping in thalamic aphasia

 10:20

Andrea Dressing (Freiburg, GER)

Using streamline-based lesion-symptom mapping to determine multi-domain post stroke deficits

 10:30

Dorothee Saur (Leipzig, GER) & Klaus Willmes  (Aachen, GER)

Discussion

 11:00     Coffee break

 Session 5 Connectivity and stroke recovery

11:15

Leonardo Bonilha (Atlanta, USA )

White matter networks and machine learning

11:35

Götz Thomalla (Hamburg, GER)

Structural connectivity - a mediator for treatment outcome in acute stroke

11:55

Ajay Halai (Cambridge, UK)

The utility of structural and functional connectivity in predicting chronic stroke aphasia

 12:10

Lukas Hensel (Cologne, Germany)

Stroke connectivity and TMS

12:20

Jonas Hosp (Freiburg, Germany)

Structural connectivity in ascending projection systems – the role of dopaminergic fibers for recovery

 12:30

Mariachristina Musso (Freiburg, GER)

Brain computer interfaces as a possible novel approach to modify network connectivity after stroke

 12:40

Cathy Price (London, UK) & Michel Rijntjes (Freiburg, GER)

Discussion

 13:10

Closing remarks

 13:20      Lunch

 3rd & 4th of February,

Hotel Stadt Freiburg
Breisacher Strasse,

FREIBURG I. BR.

This event will also be broadcasted using Webex.

Neurex workshops are part of the cycle B5 of the University of Basel. They allow students to gain Credit Points from attending workshops/meetings.

This specific workshop will give rise to the attribution of 0.5 CP.

Important: Full rules & how to proceed available here.

This event will also be broadcasted using Webex. An e-mail with the links will be sent before the event to the registered people.