Experienced scientific associate - in vivo CNS neuropharmacology / neurobiology

Publication date: November 18, 2020

Location: Allschwil (Switzerland)

We are seeking a motivated experienced Scientific Associate for a permanent position in the CNS pharmacology department starting as soon as possible

Job Responsibilities

- Design and perform pharmacological studies in rodent models of neurodegeneration based on genetic, pharmacological, misfolded protein fibril- and viral vector-mediated approaches to evaluate the neuroprotective potential of novel CNS drug candidates

- Perform neurological and behavioral evaluations (e.g., of fine motor skills, cognitive abilities, rating of clinical scores, electromyography measurements) in rats and mice. Participate to the documented selection of the most relevant tests

- Sample biological fluids (cerebrospinal fluid, blood) and tissues (brain, spinal cord, nerve, muscle) and perform biochemical analyses via different analytical methods (e.g., FACS, Western blot, Immunohistochemistry)

- Responsible for the efficient planning, analysis and documentation of experiments in a multidisciplinary environment; writing of internal scientific reports

- Communicate research findings internally, and collaborate closely with other research groups in the company

- Literature search for the setup of relevant experimental methods and optimization of existing protocols

- Supervise breeding of transgenic mouse/rat colonies, write veterinary animal licenses

Candidate’s Requirements

- Bachelor or Master degree in Science (Biology/Pharmacology/Biochemistry), ideally with additional knowledge in Neuroscience; alternatively, a technical education with longer experience on the job. Candidates holding a PhD will generally not be considered

- Recognized as an animal experimenter (LTK1 or equivalent)

- Practical work experience in the field of neuroscience of more than 5 years in academia or, preferably, in an industrial setting. Experience in the field of neurodegeneration is an asset

- Hands-on experience in animal dosing (oral gavage, subcutaneous and intraperitoneal injections), rodent behavioral pharmacology, necropsy including brain (microdissection of brain regions) and spinal cord. Experience in stereotaxic surgery is an advantage

- Experience in ex vivo cellular and tissue analysis (particularly FACS)

- Expertise in isolation of cell populations from the CNS and/or subcellular fractionation is considered a plus

- Ability to plan, methodically perform, carefully analyze, accurately document experiments and present results

- Scientifically curious, willingness to learn new techniques and skills

- Willingness to occasionally work on weekends if chronic studies are ongoing

- Excellent knowledge of English (verbal and written)

Please apply directly on Idorsia career portal.

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